Possible cyclosporin-danazol interaction in a patient with aplastic anaemia

Cyclosporin A monotherapy in young Indian aplastic anaemia patients.

Immunosuppression is the most effective treatment for patients with aplastic anaemia (AA), except for bone marrow transplantation. This may be because immune mediated stem cell suppression appears to be an important pathogenic mechanism is many patients with AA. The mechanism of action of immunosuppressives in AA is unknown. However, they may reverse abnormal immune mediated suppression of hema...

Bacterial pyomyositis in a patient with aplastic anaemia.

Bacterial pyomyositis is common in the tropids but is rare in temperate climates. A patient with aplastic anaemia who had never left the continental United States developed bacterial pyomyositis secondary to Staphylococcus aureus which responded to antibiotics and surgical drainage. Bacterial pyomyositis should be considered in the differential diagnosis of fever and myalgias in the immunocompr...

Aplastic anaemia: a review.

Aplastic anaemia is featured by bone marrow hypocellularity and peripheral pancytopenia and is a potentially fatal disease. In recent years, insight in it pathogenesis has increased. It appears that activated autoreactive T lymphocytes induce apoptosis of haematopoietic stem cells resulting in a hypocellular bone marrow. Nowadays, it can be treated by stem cell transplantation or immunosuppress...

Aplastic Anaemia.

Aplastic Anaemia in Children.

A anaemia is a life threatening blood disorder that affects a large number of children each year in India. Exposure to toxic agents like benzene, radiation and viruses like hepatitis A have been implicated in its aetiology. The incidence in developing countries is far higher compared to developed countries. Investigating a child with pancytopenia is more complex than that of an adult as numerou...